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object
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2007 degree
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number
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84
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time
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2009.8 -2010.1
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week
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order
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hours
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date
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section
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contents
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requisition
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responsible teachers and academic title
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3
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1
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2
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8.25
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1、2
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UNIT I Introduction to Pharmacology
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· Understanding the concepts such as pharmacology, drug and the contents of pharmacology study.
· Knowing of pharmacological developing history.
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Lecturer
Jin yingli
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2
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2
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8.28
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1、2
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Chapter2: Pharmacokinetics and Drug Receptors
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· Mastering the therapeutical effect and adverse reaction of drugs.
· Mastering the relationship between drug dosage and effect.
· Mastering the concepts: potency,ED50,LD50 and therapeutic index, agonist and antagonist.
· Understanding the effects and actions of drugs.
· Understanding the mechanisms of drugs action and structure-activity relationships.
· Understanding the interaction between drug and receptor.
· Knowing of transmembrane signaling and infra-cell message.
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4
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3
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2
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8.31
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3,4
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Chapter 3: Absorption, Distribution, and Elimination of Drugs
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· Mastering the in vivo procedure of drugs -ADME system.
· Mastering the concepts including first-pass elimination ,hepatic microsomal mixed function oxidase system, bioavailability, clearance, apparent volume of distribution, compartment model and half-life.
· Mastering the precluding traits of the first-order kinetics and zero-order
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4
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2
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9.4
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5,6
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· kinetics.
· Understanding the traits of active transport and passive transport.
· Understanding the concentration-time relationship and concentration-time curve.
· Understanding concentration-time curve of continuous administration and homeostasis blood-drug concentration.
· Lecture: Understanding the main pharmacokinetic parametes and significance.
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5
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5
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2
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9.7
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5,6
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Chapter4 The factors affect metabolism
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· Mastering the concepts including placebo, tolerance, resistance, habituation, addiction and dependence.
· Mastering the concepts including threshold dose, minimal effective concentration, minimal toxic amount and maximal effect.
· Knowing of the factors affecting drugs effects.
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6
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2
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9.10
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5,6
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chapter 5 The drugs Affecting the Autonomic Nervous System
chapter 6 Cholinergic Agonists
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· Knowing of the efferent neurotransmitter and receptor.
· Knowing of the basic action and classification of drugs acting on the efferent nerve system.
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Associated Pro.
Qiao ping
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6
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7
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2
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9.14
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1, 2
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· Mastering the pharmacological action and clinical application of pilocarpine acting on eyes
· Mastering the pharmacological action and clinical application of neostigmine belonging to easy-changing anti-cholinesterase drugs.
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8
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2
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9.17
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5,6
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chapter7 Cholinergic Antagonists
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· Mastering the pharmacological action , clinical application, adverse reaction and intoxication of atropine.
· Knowing of the classification of cholinoceptor blocking drugs.
· Knowing of the main traits of N receptor blocking drugs.
·
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7
8
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9
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2
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9.21
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5,6
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chapter8 Adrenergic Agonists
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· Mastering the pharmacological action and clinical application of the drugs including noradrenaline, hydroxynorephedrine, adrenaline, dopamine, ephedrine, isoprenaline, and dobutamine.
· Knowing of the chemical structure and structure activity relationship of adrenoceptor agonists.
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10
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2
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9.24
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5,6
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chapter9 Adrenoceptor blocking drugs
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· Mastering the pharmacological action and clinical application of phentolamine belonging to α receptor blocking drugs.
· Mastering the classification, pharmacological action ,clinical application ,adverse reaction and contraindication of βreceptor blocking drugs.
· Knowing of the classification of adrenoceptor blocking drugs and the representative drugs.
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11
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2
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9.28
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5,6
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chapter17 Sedative-hypnotics
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· Mastering the pharmacological action and clinical application of benzodiazepines.
· Understanding the traits of barbiturates.
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Associated Pro.
Ji Yingshi
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9
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12
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2
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10.9
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1、2
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chapter18,19 Antiepileptic drugs and Antispasmodic drugs
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· Mastering the pharmacological action and clinical application of the drugs: sodium phenytoin, carbamazepine, Phenobarbital, primidone, ethosuximide, sodium valproate and magnesium sulfate.
· Understanding the adverse reaction of the anti-epileptic drugs and antispasmodic drugs commonly used.
· Knowing of the trait of action of other anti-epileptic drugs.
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10
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13
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2
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10.12
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3,4
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Drugs acting on Parkinson's disease and affecting Alzheimer's disease
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· Mastering the pharmacological action and clinical application of the drugs : levodopa, carbidopa and trihexyphenidyl.
· Understanding the traits of action of other drugs acting on Parkinson's disease.
· Knowing of the principle of episode and the classification of drugs acting on Parkinson's disease.
· 4．Knowing of the drugs affecting Alzheimer's disease.
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14
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2
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10.15
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1、2
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chapter 20 Drugs acting on the psychiatric disorder
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· Mastering the pharmacological action, clinical application and adverse reaction of chlorpromazine.
· Mastering the pharmacological action and adverse reaction of Lithium Carbonate.
· Mastering the pharmacological action and clinical application of imipramine.
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11
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15
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2
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10.19
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3,4
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chapter 21 Analgesics
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· Mastering the pharmacological action, clinical application and adverse reaction of morphia belonging to opium Alkaloids.
· Understanding the traits of man-made synthesis opium analgesics such as pethidine
· Understanding the mechanisms of pharmacological action of analgesics.
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16
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2
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10.23
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7,8
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chapter 22 Anti-inflammatory drugs
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· Mastering the pharmacological action, clinical application and adverse reaction of aspirin and acetaminophen.
· Mastering the pharmacological action, clinical application and adverse reaction of other anti-inflammatory drugs.
· Understanding the pharmacological action and clinical application of ibuprofen.
· Understanding the identical traits of anti-inflammatory drugs.
· Knowing of the traits of action of selective COX-2 inhibitor
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12
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17
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2
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10.27
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3,4
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chapter 24 Drugs acting cardiovascular system
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· Mastering the pharmacological action, traits of action and clinical application of calcium channel blockers.
· Understanding the concepts and classification of calcium channel blockers.
· Knowing of the traits of drugs acting on k+ and Na+ channel.
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Associated Pro.
WeiZhengren
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18
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2
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10.29
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7,8
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chapter25 Anti-arrhythmic Drugs
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· Mastering the classification of anti-arrhythmic drugs.
· Mastering the pharmacological action, clinical application and adverse reaction of quinidine.
· Mastering the pharmacological action, clinical application and adverse reaction of the drugs: lidocaine, phenytoin sodium, propranolol, amiodarone and verapamil.
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19
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2
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10.30
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7,8
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· Understanding the electrophysiological background of anti-arrhythmic drugs.
· Knowing of the therapeutic principle of swift arrhythmia and the reasonable application of drugs.
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13
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20
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2
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11.2
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3、4
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chapter 27 Drugs treatment of heart failure
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· Mastering the pharmacological action, clinical application and adverse reaction of digoxin.
· Mastering the pharmacological action, mechanism, clinical application and adverse reaction of ACE inhibitor.
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14
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21
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2
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11.6
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7,8
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· Mastering the mechanism of action of βadrenoceptor blocker effecting on the treatment of CHF.
· Knowing of the pathophysiology of CHF and the link of action of drugs.
· Knowing of the application of diuresis drugs used in the treatment of CHF.
· Knowing of the main traits of positive intropic drugs belonging to non- cardenolide.
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22
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2
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11.10
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3、4
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chapter 28 Drugs used for the treatment of angina
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· Mastering the mechanisms of pharmacological action, clinical application and adverse reaction of the drugs: nitroglycerin, βadrenoceptor blocker and calcium channel blockers used for the treatment of myocardial ischemia.
· Knowing of the equilibrium relationship between the attack of angina pectoris and the supplying and consuming oxygen of myocardium.
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23
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2
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11.11
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7,8
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Chapter30 Anti-hypertensive drugs
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· Mastering the mechanism of action and clinical application of loop diuretics.
· Mastering the anti-hypertensive action, mechanism, and adverse reaction ofβ-adrenergic antagonists.
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24
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2
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11.13
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5,6
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· Mastering the anti-hypertensive action of the drugs: calcium channel blockers, angiotensin converting enzyme inhibitors, sympathetic inhibitors, AngII receptor antagonists, such as losartan and hemangiectasia drugs.
· Understanding the classification of anti-hypertensive drugs.
· Understanding the anti-hypertensive drugs in combination.
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15
16
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25
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2
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11.16
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1,2
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chapter 26 Diuretics and Dehydrat agents
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· Mastering the site and mechanisms of action of diuretics.
· Mastering the pharmacological action, clinical application and adverse reaction of furosemide belonging to high potency diuresis
· Mastering the pharmacological action, clinical application and adverse reaction of thiazides belonging to middle potency diuresis .
· Knowing of the mechanisms of action, clinical application and adverse reaction of low potency diuresis .
· Knowing of the pharmacological action, clinical application and adverse reaction.
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Lecturer
Guan fengying
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26
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2
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11.23
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3,4
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chapter 31 Drugs acting on the blood and the blood –forming organs
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· Mastering the pharmacological action, clinical application, adverse reaction and intoxication prevention of heparin and coumarin.
· Mastering the classification of anti-platelet drugs and the pharmacological action, clinical application, adverse reaction of its representive drug:aspirin
· Mastering the pharmacological action, clinical application of streptokinase belonging to fibrinolysis drugs.`
· Mastering the clinical application and adverse reaction of vitamine K belonging to promoting blood coagulative drugs
· Mastering the pharmacological action, clinical application of anti-anemia drugs: iron agents, folic acid and vitamin 12.
· Mastering the pharmacological action and clinical application of dextran.
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27
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2
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11.25
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7,8
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chapter 32 Antitussives, Expectorants and Antiasthmatic drugs
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· Mastering the mechanism of action of every variety of anti-asthmatic drugs.
· Mastering the pharmacological action, clinical application of the drugs: albuterol, terbutaline, theophylline and cromolyn sodium.
· Knowing of the clinical applications of antitussives and antitussives.
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17
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28
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2
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11.30
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3,4
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chapter 11 Adrenal Cortical Hormones
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· Mastering the pharmacological action, clinical application, adverse reaction and contraindication of adrenal cortical hormones.
· 2 Understanding the course and usage of glucocrticoids.
· Knowing of the structure-activity relationship of glucocorticoids.
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29
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2
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12.2
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7,8
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chapter 12 Thyroid and Antithyroid drugs
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· Mastering the pharmacological action ,clinical application and adverse reaction the drugs:thioureas, iodine and iodide.
· Understanding the pharmacological action and clinical application of thyroid hormone.
· Knowing of the synthesis, excretion and accommodation of thyroid hormone.
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18
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30
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2
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12.7
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1、2
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chapter 13 Insulin and Oral hypoglycemic drugs
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· Mastering the clinical application and adverse reaction of insulin preparation.
· Mastering the pharmacological action ,clinical application and adverse reaction of sulfonylureas and biguanides.
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19
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31
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2
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12.14
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3,4
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Chapter 35
Antimicrobial Drug Outline
Chapter 36
β-Lactam Antibiotics
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· The brief developing history of anti-microbial drugs.
· Nouns and terms.
· The mechanism of action of anti-microbial drugs.
· The tolerance of microorganism.
· the anti-microbial spectrum, mechanism of action, in vivo procedure and clinical application of benzylpenicillin.
· the traits of demi-synthesis penicillin; Mastering the antibacterial action and clinical application of Ampicillin and Amoxicillin.
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Professor Chen Li
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32
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2
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12.18
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5,6
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Chapter 36
（continue）
Chapter 37 Macrolide, Erythromycin
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· To know cephalosporin classification and varied representative drugs on antibiotics
· To know the erythromycin application and actions
· To know the features of Roxithromycin and Azithromycin
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20
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33
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2
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12.21
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3,4
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Chapter 38 Aminoglycosides and poly
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· the action, mechanism, clinical application and adverse reaction of aminoglycosides.
· the clinical application of aminoglycosides frequently used such as gentamicin, tobramycin and amikacin.
· Knowing of the traits of action of colistin.
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34
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2
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12.23
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7,8
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Chapter 39 Tetracyclines and Chloramphenicol
Chapter 40 Man-made synthesis Antibacterial drugs
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· the antibiotic action, clinical application and adverse reaction of chloramphenicol.
· the antibiotic mechanism, clinical applications and adverse reaction of quinolone
· the antibacterial action and mechanism of sulfonamides.
· the traits of action of SD and SMZ and the evidence and significance of TMP and sulfonamides in combination.
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21
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35
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2
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12.31
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3,4
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Chapter 42 Anti-tuberculosis drugs and antileprosy drugs
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· 1.the traits, clinical application and adverse reaction of the first-selected anti-tuberculosis drugs such as isoniazid, rifampicin and ethamnbutol.
· the main traits of the second-selected anti-tuberculosis drugs.
· the applicative principle of anti-tuberculosis drugs.
· the main traits of the anti-leprosy drugs.
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22
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36
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2
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1.7
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5,6
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Chapter 43 The available application of antibiotics
Chapter 45 Anti tumor drugs
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· The reasonable application of antibiotics
· The classification of anti tumor drugs
· To know the features of varied anti tumor drugs
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